منابع مشابه
Clinical Heterogeneity in Monogenic Diabetes Caused by Mutations in the Glucokinase Gene (GCK-MODY)
OBJECTIVE To evaluate the heterogeneity in the clinical expression in a family with glucokinase mature-onset diabetes of the young (GCK-MODY). RESEARCH DESIGN AND METHODS Members (three generations) of the same family presented either with overt neonatal hyperglycemia, marked postprandial hyperglycemia, or glucosuria. Homeostasis model assessment of insulin resistance (HOMA(IR)) and insulinog...
متن کاملMODY 2 Diabetes: An Unusual Presentation of Diabetes
Diabetes mellitus includes a heterogeneous mix of metabolic diseases characterized by chronic hyperglycemia. Some forms of this illness respond to specific etiological or pathogenic characteristics, but the underlying etiology is unknown. The most common varieties of diabetes mellitus are Type 1 and Type 2, but there are other types. Numerous common polymorphisms (approximately 50 to date) weak...
متن کامل[Mature onset diabetes of the young (MODY)].
Maturity-onset diabetes of the young (MODY) is a rare form of juvenile diabetes mellitus, defined by early onset, absence of ketosis, non-insulin-dependent diabetes and autosomal dominant inheritance. Advances in molecular genetic analysis have identified mutations accounting for different MODY subtypes, all of them associated with defects of insulin secretion. We present a case of a nine year-...
متن کاملComprehensive Maturity Onset Diabetes of the Young (MODY) Gene Screening in Pregnant Women with Diabetes in India
Pregnant women with diabetes may have underlying beta cell dysfunction due to mutations/rare variants in genes associated with Maturity Onset Diabetes of the Young (MODY). MODY gene screening would reveal those women genetically predisposed and previously unrecognized with a monogenic form of diabetes for further clinical management, family screening and genetic counselling. However, there are ...
متن کاملMutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes.
OBJECTIVE Mutations in the insulin (INS) gene can cause neonatal diabetes. We hypothesized that mutations in INS could also cause maturity-onset diabetes of the young (MODY) and autoantibody-negative type 1 diabetes. RESEARCH DESIGN AND METHODS We screened INS in 62 probands with MODY, 30 probands with suspected MODY, and 223 subjects from the Norwegian Childhood Diabetes Registry selected on...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2000
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20000912-01